KMID : 0914820090090030096
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Journal of the Korean Gastric Cancer Association 2009 Volume.9 No. 3 p.96 ~ p.103
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Clinical Significance of VEGF-C and COX-2 Expression in Gastric Carcinoma with Submucosal Invasion
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Cho Yun-Jung
Park Cho-Hyun Park Seung-Man Jeon Hae-Myung Lee Dong-Ho Ahn Chang-Joon Lee Sang-Chul Kim Jeong-Gu Lee Kwan-Ju Lee Jung-Uee
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Abstract
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Purpose: Lymph node metastasis is an important factor in determining prognosis and therapeutic options for early gastric cancer (EGC) patients. Vascular endothelial growth factor (VEGF)-C and D are known as lymphangiogenic factors, and cyclooxygenase (COX)-2 is thought to play a role in lymph node metastasis in gastric carcinoma. This study was designed to determine whether the expression of VEGF-C, VEGF-D, and COX-2 is associated with clinicopathologic factors, especially lymph node metastasis in EGCs invading the submucosa.
Materials and Methods: Tissue samples were obtained from 85 Patients undergoing standard gastrectomy with lymph node dissection between 1991 and 2007 in the Department of Surgery of Daejeon St. Mary¡¯s Hospital in Daejeon, Korea. All patients were diagnosed with gastric cancers and submucosal invasion. We examined the expression of VEGF-C, VEGF-D, and COX-2 using immunohistochemical methods.
Results: Of the 85 patients, 16 (18.8%) had lymph node metastasis. VEGF-C, VEGF-D, and COX-2 were positively expressed in 34.1% (29/85), 22.3% (19/85), and 37.6% (32/85) of the patients. VEGF-C and COX-2 expression was significantly correlated with lymph node metastasis (P£¼0.05). A positive correlation existed between VEGF-C and COX-2 expression (P£¼0.001).
Conclusion: VEGF-C and COX-2 expression is associated with lymph node metastasis in gastric cancer with submucosal invasion. VEGF-C and COX-2 may thus be predictive markers for lymph node metastasis in EGC patients with submucosal invasion.
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KEYWORD
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Early gastric cancer, VEGF-C, COX-2, Lymph node metastasis
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